Jul 30, 2022

Generic name:  biotin  (oral) [ BYE-oh-tin ]
Brand names: Appearex,  Cyto B7 , Hair, Skin & Nails
Drug class:  Vitamins

What is Appearex?

Appearex is a form of vitamin B found in foods. This medicine helps the body break down fats, carbohydrates, and proteins.

Appearex has been used in alternative medicine as a likely effective aid in treating or preventing this medicine deficiency. This medicine deficiency can be caused by malnutrition, rapid  weight loss , long-term tube feeding, and other medical conditions.

Appearex has also been used to treat seborrhea ( skin rash ) in babies. However, research has shown that this medicine may not be effective in treating this condition.

Other uses not proven with research have included treating brittle nails or thinning hair, diabetes, nerve pain, and other conditions.

It is not certain whether Appearex is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. This medicine should not be used in place of medication prescribed for you by your doctor.

Appearex is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Appearex may also be used for purposes not listed in this product guide.


Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions,  allergies , and all medicines you use.

Before taking this medicine

You should not use this product if you are allergic to Appearex.

Before using Appearex, talk to your healthcare provider. Your dose needs may be different:

  • if you have kidney disease;
  • if you have had stomach surgery; or
  • if you smoke.

Ask a doctor before using Appearex if you are pregnant or breastfeeding. Your dose needs may be different during pregnancy or while you are nursing.

Do not give any herbal/health supplement to a child without medical advice.

How should I take Appearex?

When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use Appearex, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Appearex can cause false results with certain medical tests. Tell any doctor who treats you that you are using this medicine.

The recommended dietary allowance of  biotin  increases with age. Follow your healthcare provider’s instructions. You may also consult the Office of Dietary Supplements of the National Institutes of Health, or the U.S. Department of Agriculture (USDA) Nutrient Database (formerly “Recommended Daily Allowances”) listings for more information.

It may take 3 to 6 months before the condition of your hair or nails improves.

Call your doctor if the condition you are treating with Appearex does not improve, or if it gets worse while using this product.

After you stop using Appearex, your nails will likely return to their original condition within 6 to 9 months.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra Appearex to make up the missed dose.

What happens if I overdose?

Since Appearex is a water-soluble vitamin, an overdose is unlikely to occur.

What should I avoid while taking Appearex?

Follow your healthcare provider’s instructions about any restrictions on food, beverages, or activity.

Appearex side effects

Get emergency medical help if you have signs of an allergic reaction:  hives ; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include  upset stomach  or  diarrhea .

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Appearex side effects  (more detail)

What other drugs will affect Appearex?

Taking certain medicines can lower your blood levels of biotin, which could affect your Appearex dose needs. Ask a doctor or pharmacist before using this medicine with any other medications, especially:

  • carbamazepine ;
  • phenobarbital ;
  • phenytoin ; or
  • primidone .

This list is not complete. Other drugs may affect Appearex, including prescription and over-the-counter medicines,  vitamins , and  herbal products . Not all possible drug interactions are listed here.

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