Bendeka

Jul 19, 2022

Generic name:  bendamustine  [ BEN-da-MUS-teen ]
Brand names: Belrapzo, Bendeka, Treanda
Drug class:  Alkylating agents

What is Bendeka?

Bendeka is used to treat  chronic lymphocytic leukemia . This medicine is also used to treat indolent B-cell non- Hodgkin lymphoma  after other medicines have been tried without successful treatment of this condition.

Bendeka may also be used for purposes not listed in this medication guide.

Warnings

Tell your caregivers right away if you have any type of skin rash after being treated with Bendeka.

Before taking this medicine

You should not be treated with Bendeka if you are allergic to Bendeka, polyethylene glycol, propylene glycol, or  mannitol  ( Osmitrol ).

Tell your doctor if you have ever had:

  • a weak immune system;
  • fever or other signs of infection;
  • tuberculosis ;
  • herpes zoster  (also called  shingles )
  • a metabolic disorder or electrolyte imbalance;
  • liver disease ;
  • kidney disease; or
  • if you smoke.

Using Bendeka may increase your risk of developing certain types of cancer. Ask your doctor about this risk.

Bendeka can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

  • If you are a woman, do not use Bendeka if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective  birth control  to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Bendeka.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because Bendeka can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

How is Bendeka given?

Bendeka is given as an infusion into a vein. A healthcare provider will give you this injection.

Bendeka is usually given for 2 days in a row every 21 to 28 days. Your doctor will determine how long to treat you with this medicine.

You may be given other medications to help prevent certain side effects of  bendamustine .

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

Bendeka affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.

If you’ve ever had hepatitis B, using Bendeka can cause this virus to become active or get worse. You may need frequent  liver function tests  while using this medicine and for several months after you stop.

Detailed Bendeka dosage information

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Bendeka.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving Bendeka?

Avoid driving or hazardous activity until you know how Bendeka will affect you. Your reactions could be impaired.

Bendeka side effects

Get emergency medical help if you have signs of an allergic reaction ( hives , difficult breathing, swelling in your face or throat) or a severe skin reaction (fever,  sore throat , burning in your eyes, skin pain, red or purple  skin rash  that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Bendeka may cause serious side effects. Call your doctor at once if you have:

  • fever, chills, or itching during or shortly after the injection;
  • pain, swelling, redness, skin changes, or signs of infection where the medicine was injected;
  • severe ongoing  nausea ,  vomiting , or  diarrhea ;
  • liver problems–right-sided upper stomach pain, vomiting, loss of appetite, yellowing of your skin or eyes, and not feeling well;
  • low blood cell counts–fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin,  cold hands  and feet, feeling light-headed or short of breath; or
  • signs of tumor cell breakdown–confusion, weakness, muscle cramps, nausea, vomiting, fast or  slow heart rate , decreased urination, tingling in your hands and feet or around your mouth.

Your cancer treatments may be delayed if you have certain side effects.

Common side effects of Bendeka may include:

  • fever, cough, mouth sores, trouble breathing;
  • low blood cell counts;
  • nausea, vomiting, diarrhea,  constipation ;
  • headache , tiredness;
  • rash; or
  • loss of appetite,  weight loss .

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Bendeka side effects  (more detail)

What other drugs will affect Bendeka?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially:

  • allopurinol .

This list is not complete. Other drugs may affect Bendeka, including prescription and over-the-counter medicines,  vitamins , and  herbal products . Not all possible drug interactions are listed here.

source :: https://www.drugs.com/mtm/bendeka.html