Jul 22, 2022

Generic name:  aspirin  (oral) [ AS-pir-in ]
Brand names: Arthritis Pain, Aspi-Cor, Aspir-Low, Bayer Plus, Durlaza,  … show all 8 brands
Drug classes:  Platelet aggregation inhibitors ,  Salicylates

What is Ecotrin?

Ecotrin is a salicylate (sa-LIS-il-ate) that is used to treat pain, and reduce fever or inflammation.

Ecotrin is sometimes used to treat or prevent heart attacks, strokes, and chest pain ( angina ). This medicine should be used for these conditions only under the supervision of a doctor.

Ecotrin may also be used for purposes not listed in this medication guide.


Ecotrin can cause Reye’s syndrome, a serious and sometimes fatal condition in children.

Before taking this medicine

Using Ecotrin in a child or teenager with flu symptoms or chickenpox can cause a serious or fatal condition called Reye’s syndrome.

You should not use Ecotrin if you are allergic to it, or if you have:

  • a recent history of stomach or intestinal bleeding;
  • a bleeding disorder such as hemophilia; or
  • if you have ever had an  asthma  attack or severe allergic reaction after taking Ecotrin or an NSAID (non-steroidal anti-inflammatory drug).

Tell your doctor if you have ever had:

  • asthma or seasonal  allergies ;
  • stomach ulcers;
  • liver disease ;
  • kidney disease;
  • a bleeding or blood clotting disorder;
  • gout; or
  • heart disease,  high blood pressure , or congestive  heart failure .

Taking Ecotrin during late pregnancy may cause bleeding in the mother or the baby during delivery. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using Ecotrin.

How should I take Ecotrin?

Use exactly as directed on the label, or as prescribed by your doctor.

Always follow directions on the medicine label about giving Ecotrin to a child.

Take with food if Ecotrin upsets your stomach.

You must chew the chewable tablet before you swallow it.

Do not crush, chew, break, or open an enteric-coated or delayed/extended-release pill. Swallow it whole.

Tell your doctor if you have a planned surgery.

Store at room temperature away from moisture and heat.

Do not use Ecotrin if you smell a strong vinegar odor in the this medicine bottle. The medicine may no longer be effective.

Detailed Ecotrin dosage information

What happens if I miss a dose?

Ecotrin is used when needed. If you are on a dosing schedule, skip any missed dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause stomach pain,  vomiting ,  diarrhea , vision or hearing problems, fast or slow breathing, or confusion.

What should I avoid while taking Ecotrin?

Avoid alcohol. Heavy drinking can increase your risk of stomach bleeding.

Avoid taking  ibuprofen  if you take Ecotrin to prevent stroke or  heart attack . Ibuprofen can make this medicine less effective in protecting your heart and blood vessels. Ask your doctor how far apart your doses should be.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to Ecotrin (such as  magnesium salicylate , ibuprofen,  ketoprofen , or  naproxen ).

Ecotrin side effects

Get emergency medical help if you have signs of an allergic reaction:  hives ; difficult breathing; swelling of your face, lips, tongue, or throat.

Ecotrin may cause serious side effects. Stop using Ecotrin and call your doctor at once if you have:

  • ringing in your ears, confusion, hallucinations, rapid breathing, seizure (convulsions);
  • severe  nausea , vomiting, or stomach pain;
  • bloody or tarry stools,  coughing up blood  or vomit that looks like coffee grounds;
  • fever lasting longer than 3 days; or
  • swelling, or pain lasting longer than 10 days.

Common side effects of Ecotrin may include:

  • upset stomach ,  heartburn ;
  • drowsiness; or
  • mild  headache .

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ecotrin side effects  (more detail)

What other drugs will affect Ecotrin?

Ask your doctor before using Ecotrin if you take an antidepressant. Taking certain  antidepressants  with this medicine may cause you to bruise or bleed easily.

Ask a doctor or pharmacist before using Ecotrin with any other medications, especially:

  • a blood thinner ( warfarin ,  Coumadin ,  Jantoven ), or other medication used to prevent  blood clots ; or
  • other  salicylates  such as  Nuprin   Backache  Caplet,  Kaopectate , KneeRelief,  Pamprin Cramp Formula ,  Pepto-Bismol , Tricosal, Trilisate, and others.

This list is not complete. Other drugs may affect Ecotrin, including prescription and over-the-counter medicines,  vitamins , and  herbal products . Not all possible drug interactions are listed here.

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