Generic name: cilgavimab and tixagevimab
Drug class: Antiviral combinations
What is Evusheld?
Cilgavimab in combination with tixagevimab is an experimental medicine being studied for the prevention before exposure of COVID-19 . It is not yet known if Evusheld is safe and effective.
The US Food and Drug Administration (FDA) has authorized emergency use of cilgavimab in combination with another medicine called tixagevimab for the prevention before exposure of COVID-19 in adults and people 12 years of age and older (weighing at least 40 kg or 88 lbs) who are not currently infected with COVID-19 and:
- who have not had a known recent exposure to someone infected with COVID-19;
- who are moderately to severely immunocompromised and may not get an adequate immune response to COVID-19 vaccination; or
- for whom vaccination with any COVID-19 vaccine is not recommended due to a history of severe adverse reaction to a COVID-19 vaccine.
Evusheld is not authorized for use in people:
- for treatment of COVID-19; or
- for prevention after exposure of COVID-19 in people who have been exposed to someone infected with COVID-19.
Evusheld is not a substitute for vaccination in people for whom COVID-19 vaccine is recommended. People who may benefit from COVID-19 vaccination should get vaccinated.
In people who have received a COVID-19 vaccine, Evusheld should be given at least 2 weeks after vaccination.
Evusheld may also be used for purposes not listed in this medication guide.
The US Food and Drug Administration (FDA) has authorized emergency use of cilgavimab in combination with another medicine called tixagevimab for the prevention before exposure of COVID-19 in adults and people 12 years of age and older (weighing at least 40 kg or 88 lbs).
Evusheld have not been approved to treat coronavirus or COVID-19.
Before taking this medicine
You should not use Evusheld if you are allergic to it.
Tell your doctor if:
- you had a COVID-19 vaccine;
- you have heart problems;
- you have a coagulation disorder or thrombocytopenia (low levels of platelets in the blood);
- you are pregnant or breastfeeding; or
- you have any serious or chronic disease.
COVID-19 is more likely to cause serious illness or death in a pregnant woman. Not all risks are known yet, but being treated with Evusheld is likely to be less harmful than being infected with COVID-19 during pregnancy.
How are Evusheld given?
Evusheld are injected into a muscle by a healthcare provider as two separate consecutive injections.
Evusheld can be given after 6 months of the initial consecutive injections. Follow your doctor’s instructions about receiving a repeat dose if needed.
You will be watched for at least 1 hour to make sure you do not have an allergic reaction.
Being treated with Evusheld will not make you less contagious to other people. Keep using infection control methods such as self-isolation, social distancing, hand-washing, using protective face covering, disinfecting surfaces you touch a lot, and not sharing personal items with others.
Evusheld are still being studied and all of the risks are not yet known.
What happens if I miss a dose?
Cilgavimab is given with tixagevimab in two separate consecutive injections and does not have a daily dosing schedule.
Detailed Evusheld dosage information
What happens if I overdose?
In a medical setting an overdose would be treated quickly.
What should I avoid while receiving Evusheld?
Follow your doctor’s instructions about any restrictions on food, beverages, or activity.
Evusheld side effects
Get emergency medical help if you have signs of an allergic reaction: hives ; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your medical caregivers right away if you have:
- throat irritation, swelling in your face or throat;
- dizziness , a light-headed feeling (like you might pass out);
- chest pain, wheezing, shortness of breath;
- fever, chills, sweating, nausea ;
- fast or slow heartbeats, headache , pounding in your neck or ears;
- weakness, tiredness;
- a rash or itching; or
- muscle pain.
Call your doctor if you have new or worsening symptoms after the injection, such as fever, confusion, weakness, tiredness, trouble breathing, or fast or slow heartbeats.
Common side effects of Evusheld may include:
- tiredness; or
source :: https://www.drugs.com/mtm/evusheld.html