Jul 25, 2022

Generic name: hyoscyamine [ hye-oh-SYE-a-meen ]
Brand names: Anaspaz, Ed Spaz, Hyosyne, Levbid, Levsin,  … show all 27 brands
Dosage forms: oral liquid (0.125 mg/5 mL); oral solution (0.125 mg/mL); oral tablet (0.125 mg); oral tablet, disintegrating (0.125 mg); oral tablet, extended release (0.375 mg; 0.375 mg dual-release); sublingual tablet (0.125 mg)
Drug class:  Anticholinergics / antispasmodics

What is hyoscyamine?

Hyoscyamine is used to treat many different stomach and intestinal disorders, including  peptic ulcer  and  irritable bowel syndrome . It is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid.

Hyoscyamine is sometimes used to reduce tremors and rigid muscles in people with symptoms of  Parkinson’s disease .

Hyoscyamine is also used as a drying agent to control  excessive salivation ,  runny nose , or  excessive sweating .

Hyoscyamine may also be used for purposes not listed in this medication guide.


You should not use hyoscyamine if you have urination problems, a stomach or  bowel obstruction , severe  ulcerative colitis ,  glaucoma , or  myasthenia gravis .

Before taking this medicine

You should not use hyoscyamine if you are allergic to it, or if you have:

  • a bladder obstruction or other urination problems;
  • an  enlarged prostate ;
  • a stomach or bowel obstruction (including  paralytic ileus );
  • severe ulcerative  colitis , or toxic megacolon;
  • glaucoma; or
  • myasthenia gravis.

Hyoscyamine is not approved for use by anyone younger than 2 years old.

Tell your doctor if you have ever had:

  • heart problems;
  • high blood pressure ;
  • kidney disease;
  • a  colostomy  or ileostomy;
  • a thyroid disorder; or
  • hiatal hernia  with  GERD  ( gastroesophageal reflux disease ).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I take hyoscyamine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Always follow directions on the medicine label about giving hyoscyamine to a child.

Swallow an extended-release tablet whole and do not crush, chew, or break it.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet on your tongue and allow it to dissolve. Swallow several times as the tablet dissolves. You may drink water after the pill has completely dissolved.

Store at room temperature away from moisture and heat.

Detailed Hyoscyamine dosage information

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include  headache ,  dizziness , dry mouth, trouble swallowing,  nausea ,  vomiting , blurred vision, hot  dry skin , and feeling restless or nervous.

What should I avoid while taking hyoscyamine?

Avoid taking  antacids  at the same time you take hyoscyamine.  Antacids  can make it harder for your body to absorb hyoscyamine. If you use an antacid, take it after you have taken hyoscyamine and eaten a meal.

Drinking alcohol with hyoscyamine can cause side effects.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Hyoscyamine can decrease sweating and you may be more prone to heat stroke.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Hyoscyamine side effects

Get emergency medical help if you have signs of an allergic reaction:  hives ; difficult breathing; swelling of your face, lips, tongue, or throat.

Hyoscyamine may cause serious side effects. Stop using hyoscyamine and call your doctor at once if you have:

  • anxiety , confusion, hallucinations, unusual thoughts or behavior;
  • weakness, memory problems;
  • slurred speech;
  • problems with balance or muscle movement;
  • diarrhea ; o
  • pounding heartbeats or fluttering in your chest.

Common side effects of hyoscyamine may include:

  • dizziness, drowsiness, feeling weak or tired;
  • decreased sweating, decreased urination;
  • blurred vision;
  • rash;
  • dry mouth, decreased sense of taste;
  • stomach pain, nausea, vomiting,  bloating ;
  • diarrhea,  constipation ;
  • headache;
  • sleep problems ( insomnia ); or
  • impotence , loss of interest in sex, or trouble having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Hyoscyamine side effects  (more detail)

What other drugs will affect hyoscyamine?

Tell your doctor about all your other medicines, especially:

  • an antidepressant;
  • medicine to treat mental illness;
  • cold or allergy medicine ( Benadryl  and others);
  • medicine to treat or prevent  nausea and vomiting ; or
  • an  MAO inhibitor — isocarboxazid ,  linezolid ,  methylene blue  injection,  phenelzine ,  rasagiline ,  selegiline ,  tranylcypromine , and others.

This list is not complete. Other drugs may affect hyoscyamine, including prescription and over-the-counter medicines,  vitamins , and  herbal products . Not all possible drug interactions are listed here.

source :: https://www.drugs.com/mtm/hyoscyamine.html