Jul 26, 2022

Generic name:  levetiracetam  (oral/injection) [ LEE-ve-tye-RA-se-tam ]
Brand names: Keppra, Keppra XR
Drug class:  Pyrrolidine anticonvulsants

What is Keppra?

Keppra is an anti-epileptic drug, also called an  anticonvulsant .

Keppra is a prescription medicine used to treat certain types of seizures in people with  epilepsy , including  partial onset seizures , myoclonic seizures, and  tonic-clonic seizures .

When used for partial onset seizures:

  • Keppra XR is for adults and children at least 12 years old.
  • Keppra (immediate release tablets or oral solution) may be used in children as young as 1 month old.

Keppra is also used with other seizure medications to treat tonic-clonic seizures in people who are at least 6 years old, and myoclonic seizures in people at least 12 years old.

Keppra injection is used only as an alternative for patients when oral use is temporarily not possible.


Do not stop using Keppra without first talking to your doctor, even if you feel fine. You may have increased seizures if you stop using this medicine suddenly. You may need to use less and less before you stop the medication completely.

Some people have thoughts about suicide when first taking this medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Wear a medical alert tag or carry an ID card stating that you take Keppra. Any medical care provider who treats you should know that you take seizure medication.

Keppra may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Do not start or stop taking levetiracetam during pregnancy without your doctor’s advice. Having a seizure during pregnancy could harm both the mother and the baby. Seizure control is very important during pregnancy and the benefits of preventing seizures may outweigh any risks posed by using this medicine.

Before taking this medicine

You should not use Keppra if you are allergic to levetiracetam.

To make sure Keppra is safe for you, tell your doctor if you have ever had:

  • kidney disease (or if you are on dialysis);
  • depression  or other mood problems;
  • mental illness or psychosis; or
  • suicidal thoughts or actions.

Do not give this medicine to a child without medical advice. Different brands of levetiracetam are for use only in children of certain ages.

Some people have thoughts about suicide while taking Keppra. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not start or stop seizure medication during pregnancy without your doctor’s advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor if you become pregnant. Your dose needs may be different during pregnancy.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of levetiracetam on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I take Keppra?

Take Keppra exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Keppra oral is taken by mouth at the same time each day, with or without food.

Keppra injection is given in a vein if you are unable to take the medicine by mouth.

Your dose needs may change if you switch to a different brand, strength, or form of levetiracetam. A child’s dose needs may change if the child gains or loses weight. Avoid medication errors by using only the brand, form, and strength your doctor prescribes.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Swallow the extended-release tablet whole and do not crush, chew, or break it.

Your kidney function may need to be tested.

Use all seizure medications as directed. Do not change your dose or stop using a medicine without your doctor’s advice.

Seizures may increase if you stop using Keppra suddenly.. Ask your doctor before stopping the medicine.

Wear a medical alert tag or carry an ID card to let others know you have seizures.

Store at room temperature away from moisture, heat, and light.

Detailed Keppra dosage information

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness,  agitation , aggression, shallow breathing, weakness, or fainting.

What should I avoid while taking Keppra?

Avoid driving or hazardous activity until you know how this medicine will affect you.  Dizziness  or drowsiness can cause falls, accidents, or severe injuries.

Keppra side effects

Get emergency medical help if you have signs of an allergic reaction to Keppra ( hives , difficult breathing, swelling in your face or throat) or a severe skin reaction (fever,  sore throat , burning in your eyes, skin pain, red or purple  skin rash  that spreads and causes blistering and peeling).

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression,  anxiety ,  panic attacks , trouble sleeping, or if you feel agitated, hostile, irritable, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • unusual changes in mood or behavior (unusual risk-taking behavior, being irritable or talkative);
  • confusion, hallucinations, extreme drowsiness, feeling very weak or tired;
  • loss of balance  or coordination, problems with walking or movement;
  • a skin rash, no matter how mild;
  • easy bruising, unusual bleeding; or
  • fever, chills, weakness, or other signs of infection.

Common Keppra side effects may include:

  • dizziness, drowsiness, tiredness, weakness;
  • feeling aggressive or irritable;
  • loss of appetite;
  • stuffy nose; or
  • infection.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keppra side effects  (more detail)

What other drugs will affect Keppra?

Other drugs may interact with levetiracetam, including prescription and over-the-counter medicines,  vitamins , and  herbal products . Tell your doctor about all other medicines you use.

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