Generic name:  l-methylfolate  [ L-METH-il-FOE-late ]
Brand names:  Deplin , L-Methylfolate Formula,  XaQuil XR
Drug class:  Vitamins

The L-Methylfolate Formula brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be  generic equivalents available .

What is L-Methylfolate Formula?

Folate is a form of B vitamin that occurs naturally in many foods.  Folic acid  is the man-made form of folate that is added to processed foods or vitamin and mineral supplements. Folate is needed in the human body for production of red blood cells.

A lack (deficiency) of folate in the human body can be caused by certain diseases, by taking certain medications, or by not getting enough folate in your diet. Folate deficiency can lead to decreased red blood cells, or anemia. Folate deficiency can also cause high levels of a certain amino acid in the blood, a condition called  hyperhomocysteinemia  (HYE-per-HOE-moe-sis-tin-EE-mee-a).

L-Methylfolate  Formula is a medical food for use in people who have conditions related to folate deficiency. L-Methylfolate Formula is also used in people with  major depressive disorder  who have folate deficiency, or in people with  schizophrenia  who have hyperhomocysteinemia related to folate deficiency.

L-Methylfolate Formula is not an antidepressant or anti-psychotic medication. However, L-Methylfolate Formula may enhance the effects of antidepressant medications.

L-Methylfolate Formula may also be used for purposes not listed in this medication guide.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions,  allergies , and all medicines you use.

Before taking this medicine

You should not use L-Methylfolate Formula if you are allergic to it.

To make sure L-Methylfolate Formula is safe for you, tell your doctor if you have:

  • seizures  or  epilepsy ;
  • a history of  vitamin B12 deficiency  or  pernicious anemia ; or
  • a history of  bipolar disorder  (manic  depression ).

Tell your doctor if you are pregnant or breast-feeding. Your dose needs may be different during pregnancy or while you are nursing.

How should I take L-Methylfolate Formula?

Follow all directions on your prescription label. Do not take L-Methylfolate Formula Formula in larger or smaller amounts or for longer than recommended.

Use only the strength of L-Methylfolate Formula that your doctor has prescribed. Do not switch brands without your doctor’s advice.

You may take L-Methylfolate Formula with or without food. Follow your doctor’s instructions.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Do not share this medication with another person, even if they have the same symptoms you have.

L-Methylfolate Formula is only part of a complete program of treatment that may also include other medications, and psychological counseling when used in people with depression or schizophrenia. Follow your medication and counseling routines very closely.

Store at cool room temperature away from moisture, heat, and light.

Detailed L-Methylfolate Formula dosage information

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of L-Methylfolate Formula Formula is not likely to cause life-threatening symptoms.

What should I avoid while taking l-methylfolate?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

L-Methylfolate Formula side effects

Get emergency medical help if you have signs of an allergic reaction:  hives ; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may occur, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

L-Methylfolate Formula side effects  (more detail)

What other drugs will affect L-Methylfolate Formula?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • capecitabine ;
  • fluoxetine  ( Prozac );
  • isotretinoin ;
  • methotrexate ;
  • methylprednisolone ;
  • pancrelipase ;
  • pyrimethamine;
  • triamterene ;
  • trimethoprim ;
  • warfarin  ( Coumadin ,  Jantoven );
  • birth control pills ;
  • oral diabetes medicine that contains  metformin  ( Glucophage ,  Avandamet , Metaglip, and others);
  • NSAIDs  ( nonsteroidal anti-inflammatory drugs )– aspirin ,  ibuprofen  ( Advil ,  Motrin ),  naproxen  ( Aleve ),  celecoxib ,  diclofenac ,  indomethacin ,  meloxicam , and others; or
  • seizure medicine– carbamazepine ,  lamotrigine ,  phenobarbital ,  phenytoin ,  primidone ,  valproic acid .

This list is not complete. Other drugs may interact with l-methylfolate, including prescription and over-the-counter medicines,  vitamins , and  herbal products . Not all possible interactions are listed in this medication guide.

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