Onfi

Jul 28, 2022

Generic name:  clobazam  [ KLOE-ba-zam ]
Drug class:  Benzodiazepine anticonvulsants

What is Onfi?

Onfi is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that clobazam works by enhancing the activity of certain neurotransmitters in the brain.

Onfi is used in combination with other medications to treat  seizures  caused by Lennox-Gastaut syndrome, a severe form of childhood  epilepsy  that also causes developmental and behavior problems.

Onfi in for use in patients 2 years of age or older. It is not known if this medicine is safe and effective in children less than 2 years old.

Warnings

Onfi can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol.

MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Some people have thoughts about suicide while taking seizure medicine. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

Get emergency medical help if you have a severe skin reaction (skin pain,  skin rash  with blistering).

Do not stop using Onfi without asking your doctor. You may have increased seizures or life-threatening withdrawal symptoms if you stop using the medicine suddenly after long-term use. Some withdrawal symptoms may last up to 12 months or longer.

Get medical help right away if you stop using Onfi and have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, or thoughts about suicide.

Before taking this medicine

You should not take Onfi if you are allergic to clobazam.

To make sure Onfi is safe for you, tell your doctor if you have ever had:

  • breathing problems or lung disease;
  • depression , mood problems, or suicidal thoughts or behavior;
  • a drug or alcohol addiction; or
  • liver or kidney disease.

Some people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

If you use Onfi during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Do not start or stop seizure medication during pregnancy without your doctor’s advice. Clobazam may harm an unborn baby, but having a seizure during pregnancy could harm both mother and baby. Preventing seizures may outweigh these risks. Tell your doctor right away if you become pregnant.

There may be other seizure medications that are safer to use during pregnancy.

Onfi can make hormonal  birth control  less effective, including  birth control pills , injections, implants, skin patches, and vaginal rings. Use a back-up barrier birth control to prevent pregnancy: condom,  diaphragm , cervical cap, or contraceptive sponge. Keep using birth control for at least 28 days after your last dose of Onfi.

If you are breastfeeding, tell your doctor if you notice drowsiness or feeding problems in the nursing baby.

Onfi is not approved for use by anyone younger than 2 years old.

How should I take Onfi?

Take Onfi exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides or instruction sheets. Never use Onfi in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.

Never share this medicine with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

You may take Onfi with or without food.

If you cannot swallow a tablet whole, break it in half or crush it and mix the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.

Shake the Onfi oral suspension (liquid). Measure a dose with the supplied measuring device (not a kitchen spoon).

Clobazam doses are based on weight in children and teenagers. Your child’s dose may change if the child gains or loses weight.

Seizures may increase if you stop using Onfi suddenly. Do not stop using Onfi without asking your doctor. You may have life-threatening withdrawal symptoms if you stop using the medicine suddenly after long-term use.

Store Onfi at room temperature away from moisture and heat. Keep your medicine in a place where no one can use it improperly.

Throw away any unused oral suspension 90 days after you first opened the bottle.

Dosing information

Usual Adult Dose of Onfi for Lennox-Gastaut Syndrome:

Initial total daily dose:
-Body weight 30 kg or less: 5 mg orally per day
-Body weight 30 over kg: 10 mg orally per day
Day 7 total daily dose:
-Body weight 30 kg or less: 10 mg orally per day
-Body weight over 30 kg: 20 mg orally per day
Day 14 total daily dose:
-Body weight 30 kg or less: 20 mg orally per day
-Body weight over 30 kg: 40 mg orally per day.

Usual Geriatric Dose of Onfi for Lennox-Gastaut Syndrome:

Initial dose: 5 mg orally per day
Day 7 total daily dose:
-Body weight 30 kg or less: 5 mg orally per day
-Body weight over 30 kg: 10 mg orally per day
Day 14 total daily dose:
-Body weight 30 kg or less: 10 mg orally per day
-Body weight over 30 kg: 20 mg orally per day
Maximum dose:
-Body weight 30 kg or less: 20 mg/day
-Body weight over 30 kg: 40 mg/day.

Usual Pediatric Dose of Onfi for Lennox-Gastaut Syndrome:

2 years or older:
Initial daily dose:
-Body weight 30 kg or less: 5 mg orally per day
-Body weight over 30 kg: 10 mg orally per day
Day 7 total daily dose:
-Body weight 30 kg or less: 10 mg orally per day
-Body weight over 30 kg: 20 mg orally per day
Day 14 total daily dose:
-Body weight 30 kg or less: 20 mg orally per day
-Body weight over 30 kg: 40 mg orally per day

Comments:
-Daily dose greater than 5 mg should be administered in divided doses 2 times a day.
-Doses should be escalated no more rapidly than weekly.
-Doses should be withdrawn gradually by tapering the total daily dose by 5 to 10 mg on a weekly basis until discontinued.

Use: Adjunctive treatment of seizures associated with LGS

Detailed Onfi dosage information

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of clobazam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.

Overdose symptoms may include extreme drowsiness or weakness, confusion, slow breathing, or loss of consciousness.

What should I avoid while taking Onfi?

Avoid drinking alcohol. Dangerous side effects or death could occur.

Onfi Onfi and alcohol  (more detail)

Avoid driving or hazardous activity until you know how this medicine will affect you.  Dizziness  or drowsiness can cause falls, accidents, or severe injuries.

Onfi side effects

Get emergency medical help if you have signs of an allergic reaction to Onfi ( hives , difficult breathing, swelling in your face or throat) or a severe skin reaction (fever,  sore throat , burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Onfi can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes,  anxiety ,  panic attacks , trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • weak or shallow breathing;
  • severe drowsiness, feeling like you might pass out; or
  • problems with balance or muscle movement.

Drowsiness or dizziness may last longer in older adults. Use caution to avoid falling or accidental injury.

Common Onfi side effects may include:

  • drowsiness, tiredness, trouble sleeping;
  • slurred speech;
  • anger, aggression;
  • constipation ;
  • painful urination;
  • fever, cough, breathing problems; or
  • drooling .

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Onfi side effects  (more detail)

What other drugs will affect Onfi?

Taking Onfi with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may interact with clobazam, including prescription and over-the-counter medicines,  vitamins , and  herbal products . Tell your doctor about all other medicines you use.

source :: https://www.drugs.com/onfi.html