Remdesivir

Jul 29, 2022

Generic name: remdesivir [ rem-DES-i-veer ]
Brand name:  Veklury
Dosage forms: intravenous powder for injection (100 mg); intravenous solution (5 mg/mL)
Drug classes:  Investigational drugs ,  Purine nucleosides

What is remdesivir?

Remdesivir is used to treat adults and children at least 28 days and older who weigh at least 7 pounds (3 kilograms) with positive results for  COVID-19  who are:

  • in a hospital; or
  • not in a hospital and have mild-to-moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death.

Remdesivir may also be used for purposes not listed in this medication guide.

Warnings

Remdesivir is for use only in people with COVID-19. You must remain under the care of a doctor while receiving remdesivir.

Before taking this medicine

You should not be treated with remdesivir if you are allergic to it.

Tell your doctor if you have ever had:

  • liver disease ; or
  • kidney disease.

Tell your doctor if you are pregnant or plan to become pregnant, or if you are breastfeeding.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of remdesivir on the baby.

How is remdesivir given?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using remdesivir.

Remdesivir is given as an infusion into a vein. A healthcare provider will give you this injection.

remdesivir must be given slowly, and the infusion can take 30 to 120 minutes to complete.

If you are hospitalized: remdesivir is usually given once per day for up to 10 days.

If you are not hospitalized: remdesivir is usually given once per day for 3 days.

You will need frequent blood tests to check your liver function.

You must remain under the care of a doctor while you are being treated with remdesivir for COVID-19.

What happens if I miss a dose?

Because you will receive remdesivir in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since remdesivir is given by a healthcare professional in a medical setting, you will be treated quickly if an overdose occurs.

What should I avoid while receiving remdesivir?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

Remdesivir side effects

Get emergency medical help if you have signs of an allergic reaction:  hives ; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during or after the injection. Tell your caregiver right away if you have:

  • severe  headache , pounding in your neck or ears;
  • fast, slow, or pounding heartbeats;
  • wheezing, trouble breathing;
  • swelling in your face;
  • nausea ;
  • fever, chills, or shivering;
  • itching, sweating; or
  • a light-headed feeling, like you might pass out;

Common side effects of remdesivir may include:

  • nausea; or
  • abnormal  liver function tests .

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Remdesivir side effects  (more detail)

Remdesivir dosing information

Usual Adult Dose for COVID-19:

Loading dose (Day 1): 200 mg IV as a single dose
Maintenance dose (from Day 2): 100 mg IV once a day

Duration of Therapy:
-Hospitalized patients requiring invasive mechanical ventilation and/or extracorporeal membrane oxygenation (ECMO): 10 days total
-Hospitalized patients not requiring invasive mechanical ventilation and/or ECMO: 5 days; may extend up to 5 additional days (for a total of up to 10 days) if no clinical improvement shown
-Non-hospitalized patients: 3 days total

Use: For the treatment of  coronavirus  disease 2019 (COVID-19) in patients with positive results of direct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral testing who are:
-Hospitalized, or
-Not hospitalized, have mild to moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death

Usual Pediatric Dose for COVID-19:

28 Days of Age and Older:
Weight 3 to less than 40 kg:
-Loading dose (Day 1): 5 mg/kg IV as a single dose
-Maintenance dose (from Day 2): 2.5 mg/kg IV once a day

Weight at least 40 kg:
-Loading dose (Day 1): 200 mg IV as a single dose
-Maintenance dose (from Day 2): 100 mg IV once a day

Duration of Therapy:
-Hospitalized patients requiring invasive mechanical ventilation and/or ECMO: 10 days total
-Hospitalized patients not requiring invasive mechanical ventilation and/or ECMO: 5 days; may extend up to 5 additional days (for a total of up to 10 days) if no clinical improvement shown
-Non-hospitalized patients: 3 days total

Comments:
-The lyophilized powder formulation is the only approved dosage form for pediatric patients weighing 3 to less than 40 kg.

Use: For the treatment of COVID-19 in patients with positive results of direct SARS-CoV-2 viral testing who are:
-Hospitalized, or
-Not hospitalized, have mild to moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death

Detailed Remdesivir dosage information

What other drugs will affect remdesivir?

Tell your doctor if you also take  chloroquine  or  hydroxychloroquine . Either of these other medicines could make remdesivir less effective.

Other drugs may affect remdesivir, including prescription and over-the-counter medicines,  vitamins , and  herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using.

source :: https://www.drugs.com/mtm/remdesivir.html