Jul 31, 2022

Generic name:  hyoscyamine, methenamine, methylene blue, and sodium biphosphate  [ HYE-oh-SYE-a-meen, meth-EN-a-meen, METH-il-een-BLUE, SOE-dee-um-bye-FOS-fate ]
Brand names: Urogesic-Blue,  UTA
Drug class:  Urinary antispasmodics

What is Urogesic-Blue?

Hyoscyamine  produces many effects in the body, including relief from muscle spasms.

Methenamine  and  methylene blue  work as mild antiseptics that fight bacteria in the urine and bladder.

Sodium biphosphate is a form of phosphorus, which is a naturally occurring substance that is important in every cell in the body.

Urogesic-Blue is a combination medicine used to treat bladder irritation (pain, burning, inflammation) caused by urinary tract infection. Urogesic-Blue is also used to prevent bladder discomfort during a medical procedure.

Urogesic-Blue may also be used for purposes not listed in this medication guide.


If you have an  eye exam  and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using Urogesic-Blue.

Before taking this medicine

You should not use this medicine if you are allergic to hyoscyamine, methenamine, methylene blue, or sodium biphosphate.

To make sure this medicine is safe for you, tell your doctor if you have:

  • heart disease;
  • a heart rhythm disorder;
  • congestive  heart failure ;
  • coronary heart disease ;
  • a heart valve disorder;
  • glaucoma ;
  • an  enlarged prostate  or bladder obstruction;
  • myasthenia gravis ;
  • an ulcer or obstruction in your stomach; or
  • if you are allergic to  belladonna  ( Donnatal  and others).

It is not known whether this medication will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

This medicine should not be given to a child younger than 7 years old.

How should I take Urogesic-Blue?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Do not crush, chew, or break an enteric coated pill. Swallow it whole. The pill has a special coating to protect your stomach. Breaking the pill will damage this coating.

Drink plenty of liquids while you are taking this medication.

If you have an eye exam and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using Urogesic-Blue.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Detailed Urogesic Blue dosage information

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Urogesic-Blue?

Avoid taking an antacid or anti- diarrhea  medicine within 1 hour before or after you take Urogesic-Blue.  Antacids  or anti-diarrhea medicine can make it harder for your body to absorb hyoscyamine.

If you also take  ketoconazole  ( Nizoral ), wait at least 2 hours after taking it before you take Urogesic-Blue.

Hyoscyamine, methenamine, methylene blue, and sodium biphosphate side effects

Methylene blue will most likely cause your urine or stools to appear blue or green in color. This is a normal side effect of the medication and will not cause any harm.

Get emergency medical help if you have any of these signs of an allergic reaction:  hives ; difficult breathing; swelling of your face, lips, tongue, or throat.

Urogesic-Blue may cause serious side effects. Stop using Urogesic-Blue and call your doctor at once if you have:

  • severe  dizziness , blurred vision,  fast heart rate ;
  • agitation , confusion, feeling restless or excited;
  • painful or difficult urination; or
  • shortness of breath.

Older adults may be more likely to have side effects from this medication.

Common side effects of Urogesic-Blue may include:

  • mild dizziness;
  • dry mouth; or
  • nausea ,  vomiting .

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Urogesic Blue side effects  (more detail)

What other drugs will affect Urogesic-Blue?

Many drugs can interact with this medicine. Not all possible interactions are listed here. Also, hyoscyamine can make it harder for your body to absorb other medications you take by mouth. Tell your doctor about all your medications and any you start or stop using, especially:

  • neostigmine or  pyridostigmine ;
  • bladder or urinary medicines such as  darifenacin ,  fesoterodine ,  oxybutynin ,  tolterodine ,  solifenacin ;
  • bronchodilators  such as  ipratropium  or  tiotropium ;
  • cold or allergy medicine that contains an antihistamine;
  • a diuretic or “water pill”;
  • an  MAO inhibitor — furazolidone ,  isocarboxazid ,  linezolid ,  phenelzine ,  rasagiline ,  selegiline ,  tranylcypromine ;
  • medication to treat excess stomach acid,  stomach ulcer ,  motion sickness , or  irritable bowel syndrome ;
  • medication to treat gout,  kidney stones , or an electrolyte imbalance (such as low levels of potassium);
  • medication to treat symptoms of  Alzheimer’s disease  or  Parkinson’s disease ;
  • narcotic pain or cough medication– codeine ,  fentanyl ,  hydrocodone ,  hydromorphone ,  methadone ,  morphine ,  oxycodone ,  propoxyphene , and others; or
  • sulfa drugs .

This list is not complete and many other drugs can interact with Urogesic-Blue. This includes prescription and over-the-counter medicines,  vitamins , and  herbal products . Give a list of all your medicines to any healthcare provider who treats you.

source :: https://www.drugs.com/mtm/urogesic-blue.html