Jul 31, 2022

Generic name:  hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate  [ HYE-oh-SYE-a-meen, meth-EN-a-meen, METH-il-een-BLUE, FEEN-il-sa-LIS-il-ate, SOE-dee-um-bye-FOS-fate ]
Brand names:  Azuphen MB ,  Hyolev MB ,  Phosphasal ,  UR N-C ,  Uramit MB ,  … show all 12 brands
Drug class:  Urinary antispasmodics

What is Ustell?

Hyoscyamine  produces many effects in the body, including relief from muscle spasms.

Methenamine  and  methylene blue  work as mild antiseptics that fight bacteria in the urine and bladder.

Phenyl salicylate is a mild pain reliever.

Sodium biphosphate is a form of phosphorus, which is a naturally occurring substance that is important in every cell in the body.

Ustell is a combination medicine used to treat bladder irritation (pain, spasms, inflammation) caused by urinary tract infection. Ustell is also used to prevent bladder discomfort during a medical procedure.

Ustell may also be used for purposes not listed in this medication guide.


Many drugs can interact with methylene blue. During your treatment with this medicine, do not start or stop using any other medications without your doctor’s advice.

If you take an antidepressant or psychiatric medication, call your doctor right away if you have signs of a serious drug interaction, including: confusion, memory problems, feeling hyperactive (mentally or physically), loss of coordination,  muscle twitching , shivering, sweating,  diarrhea , and/or fever.

Before taking this medicine

You should not use this medicine if you are allergic to hyoscyamine, methenamine, methylene blue, phenyl salicylate, or sodium biphosphate.

During your treatment with this medicine, do not start or stop using any other medications unless your doctor tells you to.

To make sure this medicine is safe for you, tell your doctor if you have:

  • heart disease;
  • a heart rhythm disorder;
  • congestive  heart failure ;
  • coronary heart disease ;
  • a heart valve disorder;
  • glaucoma ;
  • an  enlarged prostate  or bladder obstruction;
  • myasthenia gravis ;
  • an ulcer or obstruction in your stomach;
  • an allergy to  belladonna  ( Donnatal  and others); or
  • an allergy to  salicylates  (such as  aspirin ,  choline magnesium trisalicylate ,  magnesium salicylate ).

It is not known whether this medication will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medicine to a child without medical advice.

How should I take Ustell?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Drink plenty of liquids while you are taking this medicine.

Hyoscyamine can slow your digestion, and it may take longer for your body to absorb any medicines you take by mouth.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Detailed Ustell dosage information

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Ustell?

Avoid taking an antacid or anti-diarrhea medicine within 1 hour before or after you take hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium biphosphate.  Antacids  or anti-diarrhea medicine can make it harder for your body to absorb hyoscyamine.

If you also take  ketoconazole  ( Nizoral ), wait at least 2 hours after taking it before you take hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium biphosphate.

Ustell side effects

Get emergency medical help if you have signs of an allergic reaction:  hives ; difficult breathing; swelling of your face, lips, tongue, or throat.

This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

  • severe  dizziness , blurred vision,  fast heart rate ;
  • painful or difficult urination; or
  • shortness of breath.

Older adults may be more likely to have side effects from this medication.

Methylene blue will most likely cause your urine or stools to appear blue or green in color. This is a normal side effect of the medication and will not cause any harm.

Common side effects of Ustell may include:

  • dizziness, drowsiness;
  • dry mouth; or
  • nausea ,  vomiting .

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ustell side effects  (more detail)

What other drugs will affect Ustell?

Many drugs can interact with methylene blue. Tell your doctor about all other medications you use. You may need to stop using certain medicines (in some cases for up to 5 weeks before you start treatment with Ustell). However, do not stop taking any of your medications without your doctor’s advice. This includes:

  • any type of antidepressant;
  • diet pills, stimulants, cold or allergy medicines,  ADHD  medication;
  • narcotic pain medicine;
  • medication to treat  Parkinson’s disease  or restless leg syndrome; or
  • a “triptan”  migraine headache  medication.

Taking any of the above medications while you are treated with medicine that contains methylene blue can cause high levels of serotonin in the body. Call your doctor right away if you have symptoms of this condition:  agitation , hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, or fainting.

Many drugs can interact with this medicine. Not all possible interactions are listed here. Also, hyoscyamine can make it harder for your body to absorb other medications you take by mouth. Tell your doctor about all your medications and any you start or stop using, especially:

  • a diuretic or “water pill”;
  • medicines that change the acidity of your urine– sodium bicarbonate ,  potassium citrate , sodium citrate with citric acid or potassium;
  • bladder or urinary medicines– darifenacin ,  fesoterodine ,  oxybutynin ,  tolterodine ,  solifenacin ; or
  • a sulfa drug.

This list is not complete and many other drugs can interact with Ustell. This includes prescription and over-the-counter medicines,  vitamins , and  herbal products . Give a list of all your medicines to any healthcare provider who treats you.

source ::