Jul 31, 2022

Generic name: vilazodone [ vil-AZ-oh-done ]
Brand names:  Viibryd , Viibryd Starter
Dosage forms: oral kit (-); oral tablet (10 mg; 20 mg; 40 mg)
Drug class:  Miscellaneous antidepressants

What is vilazodone?

Vilazodone is an antidepressant that is used to treat  major depressive disorder  (MDD).

Vilazodone may also be used for purposes not listed in this medication guide.


Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Vilazodone is not approved for use by anyone younger than 18 years old.

Do not stop using vilazodone without first asking your doctor.

Before taking this medicine

Do not use vilazodone if you have used an  MAO inhibitor  in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include  isocarboxazid ,  linezolid ,  methylene blue  injection,  phenelzine ,  tranylcypromine , and others.

After you stop taking vilazodone, you must wait at least 14 days before you start taking an MAOI.

Tell your doctor if you also take stimulant medicine, opioid medicine,  herbal products , or medicine for  depression , mental illness,  Parkinson’s disease ,  migraine  headaches, serious infections, or prevention of  nausea and vomiting . An interaction with vilazodone could cause a serious condition called  serotonin syndrome .

Tell your doctor if you have ever had:

  • liver or kidney disease;
  • a bleeding or blood clotting disorder;
  • narrow-angle  glaucoma ;
  • seizures  or  epilepsy ;
  • bipolar disorder  (manic depression);
  • sexual problems;
  • drug addiction  or suicidal thoughts; or
  • if you drink alcohol.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking vilazodone during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop vilazodone without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of vilazodone on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

Not approved for use by anyone younger than 18 years old.

How should I take vilazodone?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take with food.

Your symptoms may not improve for up to several weeks.

Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.

Do not stop using vilazodone suddenly, or you could have unpleasant symptoms (such as  agitation , confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of vilazodone can be fatal.

What should I avoid while taking vilazodone?

Drinking alcohol with vilazodone can cause side effects.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as  aspirin ,  ibuprofen ,  naproxen ,  Advil ,  Aleve ,  Motrin , and others. Using an NSAID with vilazodone may cause you to bruise or bleed easily.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Vilazodone side effects

Get emergency medical help if you have signs of an allergic reaction:  skin rash  or  hives ; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes,  anxiety ,  panic attacks , trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Vilazodone may cause serious side effects. Call your doctor at once if you have:

  • a seizure (convulsions);
  • blurred vision, tunnel vision,  eye pain  or swelling, or seeing halos around lights;
  • easy bruising, unusual bleeding;
  • racing thoughts, unusual risk-taking behavior, decreased inhibitions, feelings of extreme happiness or sadness; or
  • low levels of sodium in the body– headache , confusion, slurred speech, severe weakness, loss of coordination, feeling unsteady.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering,  fast heart rate , muscle stiffness, twitching, loss of coordination,  nausea ,  vomiting , or  diarrhea .

Common side effects of vilazodone may include:

  • nausea, vomiting;
  • diarrhea; or
  • sleep problems ( insomnia ).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Vilazodone side effects  (more detail)

Vilazodone dosing information

Usual Adult Dose for Depression:

Initial dose: 10 mg orally once a day for 7 days, followed by 20 mg orally once a day for an additional 7 days
Maintenance dose: 40 mg orally once a day

Comment: This drug should be taken with food.

Use: Treatment of major depressive disorder (MDD)

Detailed Vilazodone dosage information

What other drugs will affect vilazodone?

Using vilazodone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your current medicines. Many drugs can affect vilazodone, especially:

  • any other  antidepressants ;
  • mephenytoin;
  • St. John’s wort ;
  • tramadol ;
  • a diuretic or “water pill”;
  • medicine to treat anxiety, mood disorders, or mental illness such as  schizophrenia ;
  • a blood thinner– warfarin ,  Coumadin ,  Jantoven ; or
  • migraine headache  medicine– sumatriptan ,  Imitrex ,  Maxalt ,  Treximet , and others.

This list is not complete and many other drugs may affect vilazodone. This includes prescription and over-the-counter medicines,  vitamins , and  herbal products . Not all possible drug interactions are listed here.

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